Gerresheimer: innovative silicone oil-free syringe systems

Gerresheimer has launched innovative silicone oil-free prefillable syringe systems for ophthalmic applications, which will be presented by the company at CPHI Worldwide 2024. The syringe systems made of glass or plastic ensure maximum compatibility even for sensitive ophthalmic drugs and offer functionality with precise dosage. Avoiding silicone oil reduces both particle load and possible medical side effects. The prefilled syringe (PFS) is delivered sterile and ready-to-fill with injectable drugs, designed to reduce the need for any further pretreatment.

Intravitreal injections and the special nature of ophthalmic drugs place high demands on the primary packaging of the drug and its administration. The Gx RTF syringes meet these requirements for high compatibility and functionality, including requirements for drugs based on the latest technology. For chronic eye diseases, they have proven to be a superior option to the combination of injection vials and disposable draw-up syringes due to their highly precise dosage and user-friendly handling. They are especially preferred for the administration of antineovascular agents.

Gerresheimer’s ophthalmic syringe portfolio comprises configurations of glass and COP (cyclic olefin polymer), a break-resistant and inert polymer, that does not react with the injection solution. The Gx RTF glass syringes and the Gx RTF ClearJect portfolio are now available in a silicone oil-free ophthalmic configuration. Gx RTF ClearJect syringes made of COP have an integrated Luerlock adapter that improves handling. Tighter tolerances in the production process reduce the dead volume in the syringe so that ophthalmic drugs can be dosed with high precision. Gx RTF ClearJect syringes are also free from tungsten, metal or adhesive residues and free from silicone oil residues. The resulting lower particle load reduces possible medical side effects.