The Royal Marsden NHS Foundation Trust has become the first hospital in the world to treat a patient using RaySearch Laboratories’ new adaptive replanning module in RayStation, marking a milestone in online adaptive radiotherapy. The treatment, performed in March 2025, used the Radixact® linear accelerator alongside RayStation and the hospital’s current oncology information system to deliver a personalized session to a patient with endometrial cancer.

This breakthrough demonstrates a more efficient workflow, significantly reducing treatment time while adapting to the patient’s real-time anatomy. Although some integration improvements remain, the collaboration between RaySearch and The Royal Marsden is ongoing, with plans to incorporate RayCare®—RaySearch’s oncology information system—which could further streamline and enhance clinical operations.

RaySearch emphasizes that its software ecosystem allows online adaptive radiotherapy workflows to be implemented across various machine types. The achievement reflects The Royal Marsden’s leadership in radiotherapy innovation and its commitment to personalized cancer treatment, supported by The Royal Marsden Cancer Charity and driven by advanced clinical and technological collaboration.

MedTech Spectrum's Summary

Global First in Cancer Treatment: The Royal Marsden NHS Foundation Trust is the first hospital worldwide to treat a patient using RaySearch’s new adaptive replanning module in RayStation for online adaptive radiotherapy.

Personalized and Efficient Care: The treatment enabled real-time adaptation to the patient’s anatomy, significantly reducing treatment time and enhancing personalization in cancer care.

Ongoing Innovation Collaboration: RaySearch and The Royal Marsden plan to further streamline clinical workflows by integrating RayCare®, aiming to expand the accessibility and efficiency of adaptive radiotherapy across different treatment platforms.