What is Ovarian Rejuvenation? Who Needs It?

31st March, 2025

By Dr. Kaushal Kadam, MBBS, MD, DGO and Director, Corion Fertility Clinic Pvt Ltd.

Ovarian rejuvenation is a cutting-edge medical intervention designed to enhance the ovaries' function, usually to increase egg quality and quantity in women with fertility issues. The major objective of ovarian rejuvenation is to assist women in enhancing their ovarian reserve, which can raise the odds of pregnancy, particularly when conventional fertility interventions such as IVF have not been successful.

At the heart of ovarian rejuvenation lies the treatment of Platelet-Rich Plasma (PRP) therapy. The process of drawing the patients blood, concentrating the platelets, and injecting the PRP back into the ovaries is the method in which this technique works. The concentrated platelets have growth factors that trigger cellular rejuvenation and stimulate the ovarian tissue to regrow. This procedure invites stem cells into the ovaries, which may help to enhance egg production and, theoretically, raise the prospects for conception from the womans own eggs.


Who Needs Ovarian Rejuvenation?
Ovarian rejuvenation therapy is usually indicated in women struggling with:


Low or Diminished Ovarian Reserve: Women with lower-than-normal levels of AMH (Anti- Mullerian Hormone) and fewer eggs may benefit from this procedure. A reduced ovarian reserve can make conception more challenging, and ovarian rejuvenation may offer a viable solution.


Poor IVF Response: There are women who do not yield enough eggs in IVF cycles. If the ovaries are resistant to fertility medications, PRP therapy can stimulate the ovaries to yield more eggs.


Primary Ovarian Insufficiency (POI) or Premature Menopause: Younger women with extremely low AMH levels or premature menopause might still be able to conceive with their own eggs after ovarian rejuvenation. It is particularly beneficial for those who want to steer clear of egg donation.


Poor Egg Quantity and Quality: For women facing poor egg quality or quantity, ovarian rejuvenation can be done to possibly solve the problem and enhance the chance of successful IVF procedures.


The Procedure
Ovarian rejuvenation with PRP is a less invasive technique. Blood is extracted from the patient, processed to concentrate the platelets, and injected into the ovaries. The injections are either administered laparoscopically or via transvaginal ultrasound-guided injection.

The treatment itself takes approximately 20 minutes and is under local anesthesia. It is an outpatient procedure, and patients usually go home a few hours after treatment.

Success Rate and Considerations

Although ovarian rejuvenation with PRP is as yet a new technique and an experimental one, initial research yields encouraging results. The treatment can take several weeks (typically 3-4 weeks) before any improvement becomes apparent, and the effects last for three months. However, patients need to know that the success of the treatment depends on individual factors, and not all women will react in the same way.


Conclusion
Ovarian rejuvenation provides a glimmer of hope for women that are combating reduced ovarian reserve, low-quality eggs, or poor outcomes from fertility treatment. This promising new treatment is designed to rejuvenate the ovaries, providing a possible fertility boost without the use of donor eggs. As more research comes along, the future of ovarian rejuvenation appears bright for women hoping to increase their chances of pregnancy. If you’re considering this procedure, it’s essential to consult with a fertility specialist to discuss whether ovarian rejuvenation is the right choice for you.

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