CorePlus’s recently published study marks a significant innovation in the field of cytopathology by validating the use of artificial intelligence (AI) and whole slide imaging (WSI) for 100% quality control in cervical cytology. Departing from the conventional practice of random sampling for QC, CorePlus adopted a fully digital workflow leveraging the Techcyte SureView™ platform. This system uses AI-driven object recognition to flag atypical cells across entire digitized slides, allowing every specimen to undergo a secondary review. The study, published in Cancer Cytopathology, underscores a new era of precision diagnostics, where AI enhances human expertise to create safer and more consistent screening protocols.

The importance of this development lies in its potential to redefine standards in women’s health screening. Cervical cancer prevention relies on accurate cytological interpretation, and traditional manual microscopy is both time-consuming and prone to human variability. CorePlus’s approach demonstrated outstanding diagnostic performance, with metrics such as 97% accuracy and 99% specificity using water immersion scanning. The AI system not only reduced review time but also improved the detection of squamous and glandular abnormalities compared to manual methods. By combining high-fidelity digital scanning with trained neural networks, CorePlus is addressing key challenges in diagnostic consistency and throughput.

As a result of the study’s success, CorePlus has now implemented the AI-powered WSI platform as a routine 100% QC tool in its laboratory. This represents a major step toward the full digitization of cytopathology, offering substantial benefits in diagnostic confidence, operational efficiency, and ultimately, patient care. By pioneering this model in Puerto Rico, CorePlus sets a benchmark for pathology laboratories globally, demonstrating how digital innovation and AI can be responsibly integrated into clinical practice. The initiative not only advances cytological quality assurance but also signals a broader shift toward intelligent automation in medical diagnostics.

MedTech Spectrum's Summary

AI Enables Full-Slide Quality Control: CorePlus validated the use of AI and Whole Slide Imaging to review 100% of cervical cytology slides, replacing traditional random QC sampling and enhancing diagnostic reliability.

Superior Accuracy and Efficiency: The study demonstrated high performance—97% accuracy and 99% specificity—while significantly reducing review time and improving workflow efficiency.

Setting a New Diagnostic Standard: With full implementation in routine lab operations, CorePlus establishes a new benchmark for AI-driven cytology, advancing patient care and digital pathology worldwide.