ZetrOZ Systems’ sam® 2.0 is revolutionizing arthritis care with its FDA-cleared long-duration wearable ultrasound device designed for at-home use. Built on sustained acoustic medicine (SAM) technology, sam® 2.0 delivers multi-hour, continuous ultrasound therapy that penetrates deep into soft tissue to reduce inflammation, increase circulation, and accelerate healing. Unlike traditional ultrasound treatments that are brief and clinic-based, sam® 2.0 offers a non-invasive, drug-free solution that integrates seamlessly into daily life, helping patients manage chronic joint pain more effectively.

The device has proven especially valuable for older adults dealing with knee osteoarthritis—the most common form of arthritis in the U.S. Patients like Mary Martin and Maureen Welling, both 76, report meaningful pain relief, increased mobility, and reduced dependence on medications after incorporating sam® into their routines. With its wearable, portable design, sam® empowers users to receive therapy while going about their day, improving treatment consistency and patient outcomes. Clinical studies, including randomized controlled trials, further confirm its efficacy in reducing pain and restoring function in osteoarthritis patients.

With arthritis affecting nearly 60 million U.S. adults, the importance of accessible, non-pharmaceutical treatments cannot be overstated. ZetrOZ Systems’ collaboration with the Arthritis Foundation amplifies its mission to raise awareness and expand access to effective pain management technologies. By offering a science-backed, user-friendly alternative to traditional treatments, sam® 2.0 is redefining how chronic musculoskeletal pain is managed, enabling patients to regain independence and quality of life without invasive interventions.

MedTech Spectrum's Summary

FDA-Cleared Wearable Therapy : sam® 2.0 is the only FDA-cleared long-duration ultrasound device for home use, offering a non-invasive, drug-free solution for chronic joint pain and stiffness.

Proven, Portable Relief : The device delivers multi-hour sustained acoustic medicine (SAM) therapy that reduces inflammation, increases circulation, and improves mobility—backed by clinical trials and real-world success stories.

Empowering Arthritis Patients : With arthritis affecting 60 million Americans, sam® 2.0 helps patients regain independence and quality of life, minimizing reliance on medications or invasive procedures.